- Professor, Department of Molecular and Integrative Physiology and Department of Obstetrics and Gynecology, University of Kansas Medical Center, USA
Warren B Nothnick PhD HCLD graduated from the Ohio State University with his Bachelor of Science in 1987, and his Master of Science in 1989. He did his post-doctoral fellowship at the University of Kentucky and completed his PhD there in 1994.
Research in Professor Nothnick’s laboratory focuses on deciphering the role of microRNAs (miRNAs) in the pathophysiology of endometriosis and the potential of targeting these miRNAs and/or their target transcripts as potential therapies for endometriosis treatment. miRNAs have emerged as critical post-transcriptional regulators of gene expression that are fundamental for development and function of many organ systems. Work from Professor Nothnick’s laboratory as well as that from others have shown that miRNAs are mis-expressed in endometriosis and may modulate physiological pathways relevant to endometriotic lesion survival. Emphasis is placed upon dissecting these miRNA-mediated pathways utilizing both in vitro and in vivo models. Secondary interests focus on the regulation and function of microRNAs in the decidualization process and endometrial infertility associated with endometriosis and progesterone resistance.
Recent endometriosis publications (from a total of 57 publications) include:
- Nothnick WB, Falcone T, Joshi N, Fazleabas AT, Graham A. (2017) Serum miR-451a levels are significantly elevated in women with endometriosis and recapitulated in baboons (Papio anubis) with experimentally-induced disease. Reprod Sci. 24:1195-1202.
- Nothnick, WB. (2016) Non-coding RNAs in uterine development, function and disease. Adv Exp Med Biol. 886:171-186.
- Graham A, Holbert J, Nothnick WB (2017) miR-181b-5p modulation of TIMP-3 expression during in vitro decidualization of a human endometrial stromal cell line and identification of miR-181b-5p targets by differential in-gel analysis. Reprod Sci. 24: 1264-1274.
- Nothnick WB (2017) MicroRNAs and endometriosis: distinguishing drivers from passengers in disease pathogenesis. Sem Reprod Med. 35: 173 – 180.
- Nothnick WB, Falcone T, Fazleabas AT, Olsen M, Tawfik OW, Graham A. (2018) Macrophage migration inhibitory factor receptor, CD74, is over-expressed in human and baboon (Papio Anubis) endometriotic lesions and modulates endometriotic epithelial cell survival and interleukin-8 expression. Reprod Sci (doi: 10.1177/1933719118766262).
Professor Nothnick has been a WES Ambassador since 2011.